Structural and functional analysis of fatty acid-binding proteins
نویسندگان
چکیده
منابع مشابه
Structural and functional analysis of fatty acid-binding proteins.
The mammalian FA-binding proteins (FABPs) bind long-chain FA with high affinity. The large number of FABP types is suggestive of distinct functions in specific tissues. Multiple experimental approaches have shown that individual FABPs possess both unique and overlapping functions, some of which are based on specific elements in the protein structure. Although FA binding affinities for all FABPs...
متن کاملFatty acid-binding proteins: structural and functional diversity.
Introduction Fatty acids are important molecules for all cells either as energy-delivering substrates or as precursors for synthesis of membrane lipids and lipid mediators such as thromboxanes, prostaglandins and leukotrienes, and for protein acylation. Fatty acids may directly or indirectly interact with membranes, transporters, ion channels, enzymes or hormone receptors [ l , 21. Fatty acids ...
متن کاملFatty acid transport and fatty acid-binding proteins.
Les protkines de liaison ou de transfert des acides gras sont prCsentes dans les fluides intraet extra-cellulaires de la plupart des organismes. Elles jouent un r61e dans le transport ou le ciblage des acides gras, mais peuvent kgalement agir en interaction avec different processus par la modulation de la concentration de la liaison libre. Quelques protkines de liaison des acides gras sont asse...
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BACKGROUND Fatty acid (FA) binding proteins (FABPs) of helminths are implicated in acquisition and utilization of host-derived hydrophobic substances, as well as in signaling and cellular interactions. We previously demonstrated that secretory hydrophobic ligand binding proteins (HLBPs) of Taenia solium metacestode (TsM), a causative agent of neurocysticercosis (NC), shuttle FAs in the surround...
متن کاملFatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4.
The role of fatty acid transport protein 1 (FATP1) and FATP4 in facilitating adipocyte fatty acid metabolism was investigated using stable FATP1 or FATP4 knockdown (kd) 3T3-L1 cell lines derived from retrovirus-delivered short hairpin RNA (shRNA). Decreased expression of FATP1 or FATP4 did not affect preadipocyte differentiation or the expression of FATP1 (in FATP4 kd), FATP4 (in FATP1 kd), fat...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2009
ISSN: 0022-2275
DOI: 10.1194/jlr.r800084-jlr200